Tens of thousands of Americans are hospitalized with COVID-19 every week. Thousands die from it every month. And yet, an antiviral treatment proven to lessen the chances of severe outcomes is going underused.
The drug, Paxlovid, is lauded by experts as a powerful tool that can prevent hospitalization and death from COVID-19. But the high price and doctors鈥 hesitation to prescribe the pills mean the five-day treatment isn鈥檛 getting to everyone who would benefit from it.
鈥淲hen you read in your local newspaper that in this hospital, they鈥檝e got this many COVID patients, most of those are preventable hospitalizations,鈥 said Dr. Amesh Adalja, a senior scholar at Johns Hopkins University who sees Paxlovid as a useful tool to treat COVID-19.
One Centers for Disease Control and Prevention study found that Paxlovid can risks among adults by 51%. The drug is recommended for older people and other adults with certain underlying conditions and can be prescribed for kids as young as 12.
When Paxlovid was first authorized for emergency use in the U.S. in December 2021, it was free for anyone who needed it. Once the government stopped funding the treatment, Pfizer set a list price .
The drug remains free for people on federal insurance programs like Medicaid and Medicare through the end of this year, and uninsured people also can get it for free. But many of those people must go through a run by Pfizer to get the discounts. People on commercial insurance with high out-of-pocket costs can also get financial help through a separate co-pay assistance program.
Independent pharmacy owners find Paxlovid is expensive to carry because of reimbursement rates from commercial insurers, said Kurt Proctor, a senior vice president at the 春色直播 Community Pharmacists Association.
鈥淚f you鈥檙e losing 5% on a $10 prescription, it鈥檚 very different than losing 5% on a $1,400 prescription product,鈥 he said.
The high list price also is turning off some patients.
When Celise Ballow, of Junction, Utah, got COVID-19 recently, she never got the medication.
Ballow said her doctor declined to write her a prescription after telling her it wouldn鈥檛 be covered by her insurance. Now she wonders if she could have avoided some of the infection鈥檚 worst effects if she had been able to get the medication.
鈥淚鈥檓 going on a month and a half and I鈥檓 still having nebulizer treatments. 鈥 I鈥檓 still exhausted,鈥 Ballow said.
Another factor hurting uptake appears to be the long list of medications that shouldn鈥檛 be taken with Paxlovid. Many doctors may simply decide the risk of drug interactions isn鈥檛 worth it.
鈥淚f people are on four or five different medications, it does tend to be a pain to double check 鈥榠s there an interaction here?鈥欌 said Dr. Sarah George, an infectious diseases professor at St. Louis University. Seeing a possible significant drug interaction 鈥渢ends to put a physician off from prescribing a drug, even if there is a workaround,鈥 she said.
Paxlovid isn't the only for COVID-19. Merck鈥檚 Lagevrio is another available pill, though it's proven to be less popular in the U.S. than Paxlovid. A third drug, Gilead's Veklury, is given via infusion.
The people most likely to benefit from Paxlovid were the least likely to get it in 2022, according to a
The study by Harvard researchers found that Paxlovid was disproportionately given to Medicare patients with lower risk of severe infection. If it had been properly utilized, the authors concluded, more than 16,000 COVID-19 deaths could have been prevented.
Dr. Michael Barnett, a Harvard health policy researcher who co-wrote the study, said it shouldn鈥檛 be that way.
鈥淭here are very few medications and very few patients whose potential medication interaction with Paxlovid is so severe that they鈥檙e better off not taking Paxlovid,鈥 he said. 鈥淰ery few of them are important enough that it鈥檚 a big risk to stop for a week.鈥
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